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Cyspera® Cysteamine Cream



Cyspera®is the novel pigment corrector formulated with cysteamine and free of hydroquinone to improve the appearance of stubborn discoloration.
Cyspera® is a biological depigmenting treatment for hyperpigmentation concerns.

Hyperpigmentation is a common skin condition in which some areas of the skin become darker in colour than the surrounding skin. Hyperpigmentation occurs when an excess of melanin is produced by melanocytes, the pigment cells, which are moved up to the skin’s surface.

Hyperpigmentation can be caused by inflammation, hormonal stress, sun damage, or other skin injuries. People with darker skin tones are more prone to hyperpigmentation, especially with excess sun exposure.

The active ingredient is cysteamine. Naturally present in human skin cells, cysteamine regulates melanin synthesis in the skin. It has been formulated to work as an effective topical treatment, Cyspera®.

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Clinically Proven Results

  • 92% of subjects saw significant improvement in the appearance of brown patches.
  • 67% pigment correction in the appearance of stubborn discoloration.

Ref Mansouri, P.; Farshi, S.; Hashemi, Z.; Kasraee, B. (2015).”Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial”. The British Journal of Dermatology. 173 (1): 209–217 Wang Y & Marini L “A review on the efficacy and safety of L-cysteamine as a skin depigmenting agent. AAD 2018, ePoster 7687

How to Use

The use of high SPF sunblock is highly recommended year-round for sun damage protection. Cyspera® is not a photosensitizer. It can be applied regardless of the sun intensity and on any skin phototypes. Cyspera® contains ingredients to reduce hyperpigmentation.

Intensive Phase

  • During this phase, your daily skincare routine will want to apply your cream once per day for 16 weeks.

Maintenance Phase

  • Once you hit your maintenance phase, you will only need to apply your cream once a day only two times a week. Optimal results are typically seen around 8 to 12 weeks of use.

Application Steps

  • You will want to apply your cream to dry, non-washed skin, so do not wash your face beforehand. If you have recently washed your face, then you will need to wait an hour for your application.
  • A thin layer needs to be applied to the skin. You may feel a warming sensation or mild tingling for up to 30 minutes. Leave the cream on for 15 minutes.
  • Remove the cream by washing the area with a gentle face cleanser. Pat dry.
  • End by moisturizing the area and be sure to maintain skin hydration throughout the day.


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